DEVELOPMENT OF A METHOD FOR LABORATORY DIAGNOSTICS OF ACUTE HYPOTENSIVE DRUGS POISONING
Abstract
The method of express detection of hypotensive drugs (atenolol, propranolol, nifedipine, enalaprile and verapamil) in urine samples of patients with acute poisonings was developed. The optimum conditions of group identification of hypotensive drugs using TLC were found. Analysis by GC-MS allows to detect both the native substances and their metabolites. The developed method of analysis of antihypertensive drugs can be used for the diagnosis of acute poisoning.
About the Authors
E. S. Melnikov
First MSMU named after I.M. Sechenov
Russian Federation
Russian Federation
E.S. Melnikov, post-graduate student of the chair of pharmaceutical and toxicological chemistry
M. V. Belova
First MSMU named after I.M. Sechenov
Russian Federation
Russian Federation
M.V. Belova, PhD, associate professor of the chair of pharmaceutical and toxicological chemistry
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